2.

ROS1酪氨酸激酶剂的IC₅₀

IC₅₀ of selected ROS1 tyrosine inhibitors

Drug	Manufacture (ROS1)	IC50	IC50(ALK)	Reference
TAE684	Novartis	10 nM	< 10 nM	35
Crizotinib	Pfizer	1.7 nM	0.5 nM	45
AP26113	Ariad Pharm	1.9 nM	0.69 nM	46
WZ-5-126	Ambit Bio	8.2 nM	3.4 nM	35
ASP3026	Astellas	n/a	n/a	46
AZD1480	AstraZeneca	n/a	n/a	43
KIST301072	Korea Insitute	199 nM		44
KIST201080	of Sci. and Tech	209 nM		44