3.
OS多因素分析
Multivariate analysis of overall survival
| Variable |
Patients n (%) |
Median OS (mo) |
P
|
HR (95%CI) |
| OS: overall survival; CI: confidence interval; HR: hazard ratio. | ||||
| Age (yr) | 0.217, 6 | 0.641 (0.316-1.300) | ||
| ≥65 | 18 | 7.6 | ||
| < 65 | 43 | 9.0 | ||
| Gender | 0.971, 8 | 0.982 (0.360-2.677) | ||
| Male | 17 | 8.0 | ||
| Female | 44 | 8.5 | ||
| Smoking status | 0.840, 7 | 0.880 (0.252-3.074) | ||
| Never | 51 | 8.5 | ||
| Current or ever | 10 | 8.0 | ||
| ECOG | 0.177, 7 | 0.637 (0.379-1.197) | ||
| 0-1 | 30 | 11.0 | ||
| ≥2 | 31 | 7.5 | ||
| EGFR mutation | 0.321, 7 | 0.653 (0.346-1.289) | ||
| (+) | 34 | 8.0 | ||
| (-) | 4 | 9.8 | ||
| Number of metastasized organs | 0.425, 2 | 0.706 (0.300-1.611) | ||
| 1-2 | 40 | 8.5 | ||
| ≥3 | 21 | 8.0 | ||
| Metastasized region | ||||
| Lung | 47 | 9.0 | 0.471, 5 | 0.750 (0.343-1.640) |
| Brain | 30 | 7.25 | 0.492, 5 | 0.777 (0.377-1.599) |
| liver | 12 | 8.75 | 0.245, 8 | 0.608 (0.262-1.408) |
| Bone | 27 | 7.2 | 0.517, 1 | 0.801 (0.409-1.568) |
| Response of initial TKI | 0.490, 1 | 0.755 (0.339-1.681) | ||
| CR+PR | 44 | 8.5 | ||
| SD | 17 | 8.0 | ||
| PFS of initial TKI | 0.217, 3 | 0.456 (1.131-1.588) | ||
| ≥6 months | 55 | 8.5 | ||
| < 6 months | 6 | 12.15 | ||
| Interval chemotherapy | 0.866, 9 | 0.971 (0.331-2.535) | ||
| Yes | 50 | 9.0 | ||
| No | 11 | 5.0 | ||
| Interval time | 0.008, 0 | 0.262 (0.097-0.705) | ||
| ≥3 months | 50 | 9.0 | ||
| < 3 months | 11 | 5.0 | ||