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56例肺腺癌患者临床特征与疗效分析

Analysis of the characteristics and response of 56 patients

Characteristics	n (%)	CR	PR	SD	PD	ORR (%)	P	DCR (%)	P
PS: performance status; EGFR: epidermal growth factor receptor; CR: complete response; PR: partial response; SD: stable response; PD: progressive disease; ORR: objective response rate; DCR: disease control response.
Gender							0.785		0.108
Male	21 (37.5)	0	9	5	7	42.9		66.7
Female	35 (62.5)	0	17	13	5	48.6		85.7
Age (yr)							0.999		0.999
< 70	26 (46.4)	0	12	8	6	46.2		76.9
≥70	30 (53.6)	0	14	10	6	46.7		80.0
PS (ECOG)							0.087		< 0.001
0-2	46 (82.1)	0	24	18	4	52.2		91.3
3-4	10 (17.9)	0	2	0	8	20.0		20.0
Smoker							0.038		0.017
Never	36 (64.3)	0	20	13	3	55.6		86.1
Light	7 (12.5)	0	4	1	2	57.1		71.4
Non-light	13 (23.2)	0	2	4	7	15.4		46.2
Stage							0.592		0.522
Ⅲb	3 (5.4)	0	2	0	1	66.7		66.7
Ⅳ	53 (94.6)	0	24	18	11	45.3		79.2
EGFR mutation							0.010		0.129
19 deletion	10 (17.9)	0	9	1	0	90.0		100.00
L858R	8 (14.3)	0	3	4	1	37.5		87.5
Wild type	2 (3.6)	0	0	1	1	0.00		50.0
Unknown	36 (64.3)	0	14	12	10	38.9		72.2
Rash							0.043		0.012
No	40 (71.4)	0	15	13	12	37.5		70.0
Yes	16 (28.6)	0	11	5	0	68.8		100.00
Diarrhea							0.358		0.666
No	50 (89.3)	0	25	13	12	50.0		76.0
Yes	6 (10.7)	0	1	5	0	16.7		100.00