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. 2018 Jun 7;5:51. doi: 10.3389/fmolb.2018.00051

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Copyright © 2018 Roe, Wahab, Török, Horváth, Vigh and Prodromou.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of nucleotide on LA1011 binding and effects on or with co-chaperone interaction. Binding of LA1011 to (A) yeast Hsp90-ADP complex; (B) yeast Hsp90–AMPPNP complex, and (C) Hsp90-AMPPNP-Sba1 complex. (D) Binding of Sti1 to Hsp90-LA1011 complex. Nucleotide appears to decrease the affinity for LA1011, while LA1011 has little effect on Sti1 binding itself, based on previous studies (Prodromou et al., 1999). Sba1 weakens LA1011 binding slightly. Red lines in ITC figures represent heat of dilution, while the black fittings represent the corrected heat of interaction for the experiment.