1.
上调基因及其功能简述
The up-regulated genes and brief introdutions of their functions
| Name | Gene-id | Ratio | Function |
| MET | ENSG00000105976 | 9.991 8 | The hepatocyte growth factor receptor, play a critical role in aggressive cancers such as breast cancer or SCLC. |
| UGDH | ENSG00000109814 | 9.941 3 | The protein encoded by this gene plays roles in signal transduction, cell migration, and cancer growth and metastasis. |
| C8orf4 | ENSG00000176907 | 8.241 3 | This gene encodes protein that functions as a positive regulator of the Wnt/beta-catenin signaling pathway, which upstream regulator of the Wnt/beta-catenin pathway that enhances aggressive behavior of cancers. |
| FOS | ENSG00000170345 | 7.980 4 | The FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. In some cases, expression of the FOS gene has also been associated with apoptotic cell death. |
| SDCBP | ENSG00000137575 | 5.800 5 | The protein encoded by this gene enhanced tumor cell invasion and metastatic spread. |
| ADAM10 | ENSG00000137845 | 5.212 3 | Members of the ADAM family, interfere with cell-cell adhesion and enhance migration of cancer cells. |
| ITGB1 | ENSG00000150093 | 4.883 7 | Integrin family members are membrane receptors involved in cell adhesion and recognition in a variety of processes including embryogenesis, hemostasis, tissue repair, immune response and metastatic diffusion of tumor cells. |
| MCL1 | ENSG00000143384 | 4.717 8 | The protein encoded by this gene belongs to the Bcl-2 family. Te longer gene product enhances cell survival by inhibiting apoptosis while the alternatively spliced shorter gene product promotes apoptosis and is death-inducing. |
| LAMP2 | ENSG00000005893 | 4.503 3 | The protein encoded by this gene is a member of a family of membrane glycoproteins. It may play a role in tumor cell metastasis. |
| CASP8 | ENSG00000064012 | 4.374 0 | This gene encodes a member of the cysteine-aspartic acid protease (caspase) family, it plays a central role in the execution-phase of cell apoptosis. Coding polymorphisms of it may play a role in predisposition to lung cancer. |
| ZNF217 | ENSG00000171940 | 4.311 7 | The protein encoded by this gene might play a crucial role in the proliferation and invasion of ovarian cancer. |
| HSPAS | ENSG00000044574 | 4.300 9 | Upregulation of this gene can signifcantly confer the chemoresistance to VP-16 in human lung cancer cell line SK-MES-1. |
| CEACAM5 | ENSG00000105388 | 4.157 5 | The protein encoded by this gene is a risk factor for brain metastasis development and is associated with poor prognosis in patients with advanced NSCLC. |
| DUSP1 | ENSG00000120129 | 4.066 9 | The protein encoded by this gene plays a role in progression of non-small cell lung cancer |
| Q6P709_HUMAN | ENSG00000143549 | 3.925 6 | This gene encodes a member of the tropomyosin family of actin-binding proteins and it may play a role in cancer cell invasion and metastasis. |
| HNRPH2 | ENSG00000126945 | 3.916 8 | The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA), and it plays a role in tumor cell proliferation. |
| CCL20 | ENSG00000115009 | 3.890 3 | Contribute to tumor growth and metastases. |
| CAPG | ENSG00000042493 | 3.890 0 | This gene encodes a member of the gelsolin/villin family of actin-regulatory proteins that promotes cell invasion. |
| PLAUR | ENSG00000011422 | 3.872 7 | A useful predictors of distant metastases, may interact with multiple integrins in normal human lung fbroblasts thereby promoting atachment, spreading, and migration. |
| AXL | ENSG00000167601 | 3.813 7 | Activation of this gene may be a protective mechanism against hypertonicity-induced apoptosis, and is associated with lung adenocarcinoma and with tumor progression. |
| EREG | ENSG00000124882 | 3.695 3 | A member of the epidermal growth factor family. Expression of this gene correlates with advanced disease, is EGFR dependent, and confers invasive properties on non-small cell lung cancer cells. |
| CEACAM6 | ENSG00000086548 | 3.539 3 | This gene silences reversed the acquired anoikis resistance of tumor cell lines and inhibited in vivo metastatic ability. |
| PTGES | ENSG00000148344 | 3.535 9 | The protein encoded by this gene is associated with metastasis in non-small cell lung cancer. |
| BNIP3 | ENSG00000197358 | 3.242 | A survival mechanism during hypoxia-induced autophagy that promotes tumor progression. |
| RAD21 | ENSG00000164754 | 2.984 8 | This gene was closely related to the invasion and metastasis of cancer cells. |