2.
下调基因及其功能简述
The down-regulated genes and brief introdutions of theri functions
| Name | Gene-id | Ratio | Function |
| MCM2 | ENSG00000073111 | 0.306 0 | The protein encoded by this gene is an highly conserved mini-chromosome maintenance proteins. Expression of it was associated with the tumors' histological grade, existence of nodular metastases, malignancy on adenoma, and vascular invasion. |
| CCND3 | ENSG00000112576 | 0.307 2 | This protein encoded by this gene has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. |
| OSGIN1 | ENSG00000140961 | 0.318 6 | A novel p53 target gene that is regulated by Peptidylarginine deiminase 4 and plays a role in apoptosis. |
| FGFR1 | ENSG00000077782 | 0.320 7 | A member of FGFR family, plays roles in cancer growth and metastasis. |
| SLC3A2 | ENSG00000168003 | 0.323 2 | This gene is a member of the solute carrier family and encodes a cell surface, transmembrane protein. It associates with integrins and mediates integrin-dependent signaling related to normal cell growth and tumorigenesis. |
| HSPA1A | ENSGOOOOO204389 | 0.373 4 | This intronless gene encodes a 70 kDa heat shock protein,which induces proteasome-dependent degradationof HSP90 client proteins, G1 cell-cycle arrest, and extensive tumor-specifc apoptosis in human tumor cell lines. |
| SFN | ENSG00000175793 | 0.387 5 | A lymph node metastasis-related protein in human lung squamous carcinoma and also enhance p53 degradation, thereby inhibiting p53-mediated cell death. |
| TACC3 | ENSG00000013810 | 0.399 8 | The function of this gene is that it may be involved in cell growth and differentiation. Expression of this gene is up-regulated in some cancer cell lines. |
| EVL | ENSG00000196405 | 0.421 4 | This gene is suppressed in human cancers such as colorectal. |
| PA2G4 | ENSG00000170515 | 0.426 7 | This gene encodes an RNA-binding protein that is involved in growth regulation. It suppresses gene transcription and tumorigenesis of prostate cancer cells. |
| E2F1 | ENSG00000101412 | 0.443 4 | The protein encoded by this gene is a member of the E2F family of transcription factors. It can mediate both cell proliferation and p53-dependent/independent apoptosis. |
| DDX18 | ENSG00000088205 | 0.473 1 | This gene is important for cell proliferation and that its inhibition could prevent tumor cell proliferation |
| Q5SQ38_HUMAN | ENSGOOOOO204463 | 0.485 2 | This gene encodes a nuclear protein that is implicated in the control of apoptosis. It forms a complex with E1A binding protein p300 and is required for the acetylation of p53 in response to DNA damage. |