3.
ENT3 rs10999776多态位点基因型联合吸烟与肺癌风险性的关系
The relationship between the genotypes of rs10999776 combined with smoking and the risk of lung cancer
| Genotypes | Smoking history (packs/year) | Lung cancer (n=351, %a) | Control (n=207, %a) | OR (95%CI) | P | ORb (95%CI) | P |
| a: parentheses display constituent ratio; b: OR adjusted by age and gender. | |||||||
| CC | Non-smokers | 86 (24.5) | 60 (29.0) | 1.000 | 1.000 | ||
| Smokers | 98 (27.9) | 61 (29.5) | 1.121 (0.708-1.774) | 0.626 | 0.985 (0.643-1.621) | 0.702 | |
| < 30 | 25 (25.5) | 32 (52.5) | 0.545 (0.294-1.012) | 0.053 | 0.623 (0.375-1.233) | 0.051 | |
| > 30 | 73 (74.5) | 29 (47.5) | 1.756 (1.021-3.020) | 0.041 | 2.305 (1.337-3.854) | 0.037 | |
| TC+TT | Non-smokers | 68 (19.4) | 51 (24.6) | 0.930 (0.570-1.519) | 0.773 | 1.124 (0.604-1.623) | 0.887 |
| Smokers | 99 (28.2) | 35(16.9) | 1.973 (1.188-3.277) | 0.008 | 2.848 (1.536-4.879) | 0.005 | |
| < 30 | 33 (33.3) | 15(42.9) | 1.535 (0.767-3.071) | 0.224 | 1.637 (0.859-3.986) | 0.159 | |
| > 30 | 66 (66.7) | 20(57.1) | 2.302 (1.265-4.192) | 0.006 | 3.076(2.308-6.741) | 0.001 | |