Table 3.

Demographic and genetic characteristics of 474 patients with medullary thyroid carcinoma in Denmark, 1960–2014.

Category	1960–1996	1997–2014	1960–2014
SMTC
Total	185	171	356
Female:male	104:81	106:65	210:146
Mean age at diagnosis, years (95% CI)	57.9 (55.5–60.3)	57.1 (54.7–59.4)	57.5 (55.8–59.2)
Diagnosed by autopsy	13	4	17
HMTC
Total	60	53	113
Female:male	28:32	26:27	54:59
Mean age at diagnosis, years (95% CI)	44.8 (40.3–49.4)	37.2 (32.4–42.0)	41.2 (37.9–44.6)
Diagnosed by autopsy	1	0	1
RET mutation carriers
C611W	1	3	4
C611Y	40	31	71
C618F	1	1	2
C618Y	2	3	5
C620R	3	4	7
D631Y	1	0	1
C634R	7	1	8
C634R + Y791F	0	1	1
L790F	0	1	1
V804M	1	1	2
A883F	0	1	1
M918T	0	6	6
Unknown	4a	0	4a
Unclassified
Total	5	0	5
Female:male	3:2		3:2
Mean age at diagnosis, years (95% CI)	59.0 (47.2–70.8)		59.0 (47.3–70.8)
Diagnosed by autopsy	1		1

Figures indicate number of patients unless otherwise stated.

^aAll patients had phenotypically MEN2B and have been described elsewhere (12).

HMTC, hereditary medullary thyroid carcinoma; RET, rearranged during transfection; SMTC, sporadic medullary thyroid carcinoma.