Figure 3. 3. Effect of PD98059 and amentoflavone on the expression of tumor progression-associated proteins in SK-Hep1 cells. Cells were treated with 10 μM PD98059, or different concentrations (0, 100, 200 μM) of amentoflavone for 48 h, respectively. Protein levels of MMP-9, XIAP, VEGF, cyclin-D1, and pERK were evaluated with western blotting assay. (A) PD98059 treatment, (B) Amentoflavone treatment.