Table 4.
Analysis of relationships between vimentin and clinicopathological variables in CRC.
| Clinical pathological variable | Study (N) | Pooled OR (95%CI) |
p value | Heterogeneity test | ||
|---|---|---|---|---|---|---|
| Q | I2 (%) | p | ||||
| Age (≤60/>60) | 6 | 0.964(0.742-1.253) | 0.786 | 1.368 | 0.000 | 0.928 |
| Tumor size (>5cm/≤5cm) | 5 | 0.782(0.581-1.053) | 0.105 | 2.582 | 0.000 | 0.630 |
| Gender (male/female) | 10 | 0.943(0.761-1.169) | 0.594 | 5.800 | 0.000 | 0.760 |
| Tumour site (Colon/Rectum) | 5 | 0.929(0.690-1.250) | 0.626 | 3.835 | 0.000 | 0.429 |
| CEA level (>5ng/ml/≤5 ng/ml) | 3 | 0.937(0.650-1.352) | 0.728 | 1.559 | 0.000 | 0.459 |
| Differentiation (poor/well or mod) | 8 | 0.954(0.407-2.234) | 0.914 | 53.357 | 86.881 | 0.000 |
| Lymph node metastasis (present/absent) | 4 | 2.288(1.159-4.517) | 0.017∗ | 5.717 | 47.520 | 0.126 |
| Distant metastasis (present/absent) | 2 | 4.122(0.820-20.730) | 0.086 | 2.551 | 60.807 | 0.110 |
| Recurrence (present/absent) | 2 | 3.726(0.215-64.509) | 0.366 | 5.993 | 83.314 | 0.014 |
| Lymphovascular invasion (present/absent) | 4 | 1.244(0.736-2.103) | 0.415 | 6.367 | 52.883 | 0.095 |
| Venous invasion (present/absent) | 3 | 1.180(0.220-6.328) | 0.847 | 3.912 | 48.880 | 0.141 |
| TNM stages (III-IV/I-II) | 4 | 1.957(1.333-2.873) | 0.001∗ | 1.973 | 0.000 | 0.578 |
| T stage (T3–T4/T1–T2) | 3 | 0.756(0.520-1.098) | 0.142 | 1.242 | 0.000 | 0.537 |
| N stage (N1–N2/N0) | 3 | 2.316(1.482-3.620) | 0.000∗ | 2.515 | 20.477 | 0.284 |
N, the number of the included studies; CEA, carcinoembryonic antigen; CRC, colorectal cancer.
∗: the value of p<0.05 indicates statistical significance.