. 2018 Jun 14;18:59. doi: 10.1186/s12866-018-1199-3

Table 2.

Summary of changes in the Tat-secreting strain observed using model iJV710

Pathway	Tat-secreting vs. Sec-secreting				Tat-secreting vs. Plasmid-bearing
Pathway	N	N_AMN	P _{alt = Tat < Sec}	P _{alt = Tat > Sec}	N	N_AMN	P_{alt = Tat < pIJ486}	P_{alt = Tat > piJ486}
Carbon sources	138	26	0.540	0.021	138	29	0.110	0.733
Sulphate metabolism	5	4	0.105	1	5	4	0.779	0.105
Glycolysis	23	13	0.0004	0.9259	23	13	0.002	0.926
TCA cycle	34	18	0.233	0.777	34	19	0.289	0.721
PPP	16	9	0.046	0.962	16	9	0.0002	0.999
Anaplerosis	13	5	0.147	0.896	13	5	0.264	0.799
Energy metabolism	9	6	0.409	0.650	9	6	0.591	0.469
Amino acid biosynthesis	90	56	0.168	0.417	90	64	0.0001	1
Nucleotide biosynthesis	81	45	0.00014	0.978	81	46	0.0004	0.916
Lipid biosynthesis	49	36	0.0001	1	49	37	0.0004	0.973
Cofactor biosynthesis	54	41	0	0.976	54	42	0	0.976
Macromol. biosynthesis	10	10	0.095	0.917	10	10	0.109	0.905

Comparisons of the Tat-secreting strain using the model iJV710 based on MTF analysis of the AMN with pathways grouped in broad subsystems. N is the number of reactions in the subsystem, N_AMN is the number of subsystem reactions that are active in either of the two strains being compared, P is the P value obtained using the specified alternative hypothesis (i.e. when P < 0.05 the specified alternative hypothesis cannot be rejected). Only subsystems with N_AMN > 4 are reported

Abbreviations: TCA cycle tricaboxylic acid (Krebs) cycle, PPP pentose phosphate pathway