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. 2018 Jun 13;19:455. doi: 10.1186/s12864-018-4844-1

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — The absolute difference in the modification levels of histones H3K27me3 and X5mC. a, b Intrachromosomal colocalization strengthens the co-modification of H3K27me3 and X5mC in evolutionary neighboring gene pairs and always-neighboring gene pairs. c, d Evolutionary neighboring and always-neighboring relationships cause mutual enhancement in the modification levels of histones H3K27me3 and X5mC. e, f The similarities in the histone modification levels of different combinations of colocalizations. Error bars were calculated by bootstrapping. Significance values calculated from the Mann–Whitney U test are shown