Fig. 5.

CoQ10 suppresses activation of caspase-3 induced by STS treatment. Control, MIN6 cells cultured in regular medium; STS, cells exposed to STS (0.5 µM for 12 h); CoQ10, cells pretreated with CoQ10 (30 µM for 4 h) and then exposed to STS (0.5 µM for 12 h); Z-VAD, cells pretreated with Z-VAD-FMK (30 µM for 1 h) and then exposed to STS (0.5 µM for 12 h). Cleaved caspase-3 is the active form of caspase-3. STS induced activation of caspase-3, but CoQ10 suppressed this activation