Table 2.
Distribution of SG-adjusted trimester specific urinary phthalate metabolites measured during pregnancy among 245 women1 from EARTH study
| Phthalate metabolites | Trimester | Number | Detection frequency2 | SG-adjusted concentrations | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| geometric (SD) | min | 25th | 50th | 75th | 95th | max | ||||
| MEP (ng/mL) | 1 | 208 | 100% | 43.6 (4.4) | 3.33 | 15.3 | 31.96 | 96.54 | 586.74 | 12,600 |
| 2 | 209 | 100% | 60.2 (6.1) | 2.96 | 21.99 | 47.99 | 144.2 | 1024 | 4791 | |
| MBP (ng/mL) | 1 | 208 | 99.5% | 10.9 (0.6) | <LOD | 6.61 | 10.47 | 16.21 | 40.37 | 2186 |
| 2 | 209 | 97.6% | 11.8 (0.9) | <LOD | 6.83 | 11.95 | 21 | 64.52 | 1699 | |
| MiBP (ng/mL) | 1 | 208 | 96.6% | 5.7 (0.3) | <LOD | 3.45 | 5.82 | 9.97 | 19.6 | 52.85 |
| 2 | 209 | 97.6% | 5.7 (0.4) | <LOD | 3.29 | 6.16 | 10.11 | 24.36 | 152.35 | |
| MBzP (ng/mL) | 1 | 208 | 95.7% | 3.0 (0.2) | <LOD | 1.51 | 2.87 | 5.02 | 18.2 | 285.06 |
| 2 | 209 | 91.9% | 2.9 (0.2) | <LOD | 1.41 | 2.8 | 5.37 | 26.21 | 369.6 | |
| MCPP (ng/mL) | 1 | 208 | 98.1% | 4.9 (0.5) | <LOD | 1.67 | 3.81 | 12.52 | 77.78 | 651.72 |
| 2 | 209 | 96.7% | 3.7 (0.3) | <LOD | 1.69 | 2.9 | 6.46 | 45.13 | 486.5 | |
| MCOP (ng/mL) | 1 | 192 | 97.9% | 28.2 (2.9) | <LOD | 10.46 | 28.28 | 76.39 | 322 | 687.27 |
| 2 | 190 | 97.4% | 21.9 (2.3) | <LOD | 7.7 | 20.38 | 60.39 | 322 | 659.17 | |
| MCNP (ng/mL) | 1 | 192 | 93.2% | 4.2 (0.3) | <LOD | 1.87 | 3.36 | 7.66 | 29.65 | 239 |
| 2 | 190 | 92.6% | 3.5 (0.3) | <LOD | 1.75 | 2.99 | 6.3 | 30.05 | 209.07 | |
| ∑DEHP(nmol/mL) | 1 | 208 | 0.2 (0.02) | 0.02 | 0.09 | 0.15 | 0.36 | 2.71 | 17.89 | |
| 2 | 209 | 0.1 (0.01) | 0.01 | 0.07 | 0.12 | 0.23 | 1.5 | 8.21 | ||
Abbreviations: min minimum, max maximum, SG specific gravity, N number of women = number of urine samples, MEP monoethyl phthalate, MBP mono-n-butyl phthalate, MiBP mono-isobutyl phthalate, MBzP monobenzyl phthalate, MCPP mono-3(carboxypropyl) phthalate, MCOP monocarboxyisooctyl phthalate, MCNP monocarboxyisononyl phthalate, DEHP di-2(ethylhexyl) phthalate
1Of 245 women, 208 women provided 1st trimester urine sample, and 209 women provided 2nd trimester urine sample.
2Percent of phthalate metabolite concentrations above the limits of detection (LODs). LODs were 0.4–0.8 μg/L for MEP; 0.4–0.6 μg/L for MBP; 0.2–0.3 μg/L for MiBP; 0.2–0.3 μg/L for MBzP; 0.1–0.2 μg/L for MCPP; 0.2–0.7 μg/L for MCOP; 0.2–0.6 μg/L for MCNP; 0.5–1.2 μg/L for MEHP, 0.2–0.7 μg/L for MEHHP and MEOHP; and 0.2–0.6 μg/L for MECPP.