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. 2018 Jun 14;6:54. doi: 10.1186/s40425-018-0363-5

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Effect on APTT, blood lipids and AST of weekly IV dosing in beagle dogs and humans (patients in the 100 mg cohort). APTT (a), cholesterol (b), triglycerides (c) and AST (d) were measured in the blood of dogs after 5 pixatimod doses (weekly dosing). Treatment averages indicated with short solid horizontal lines. Corresponding data from the six 100 mg patients for these 4 parameters are presented over time. Dotted lines represent upper limit of the normal range for each parameter. * = P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001 versus control (Kruskal-Wallis test)