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. 2018 Jun 14;6:54. doi: 10.1186/s40425-018-0363-5

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — The relationship between a single pixatimod dose and exposure (AUC) across mouse, dog and human. The Week 1 AUC_0-last data from Table 1 are plotted as a function of the human equivalent dose (HED). The dotted line represents a linear regression of all of the data yielding an R² of 0.9669 and a y intercept of 112.59