Fig. 6.

Efficacy of pixatimod in combination with anti-PD-1 in a syngeneic 4T1.2 breast cancer mouse model. a Seven days after inoculation, mice were randomised into four treatment groups of six mice each: Control (PBS weekly plus 200 μg isotype antibody twice weekly); Pixatimod (pixatimod 15 mg/kg weekly plus isotype antibody twice weekly); Anti-PD-1 (PBS weekly plus 200 μg anti-PD-1 antibody twice weekly) and Combination (pixatimod weekly plus anti PD-1 antibody twice weekly). Satellite groups of four mice were treated identically and were stopped at day 11 for immune cell analysis (Fig. 6). b Tumor volumes were measured throughout the study and the means compared at study conclusion (day 18). **P < 0.01 versus control