Fig. 2. (a) TEM image of swollen mitochondria. The cells were treated with OnIr1 (1 μM, 24 h). (b) ATP deletion assay for A549R cells incubated with OnIr1–OnIr4 for 48 h. Incubation with OnIr1 and OnIr2 was performed at a concentration of (A) 0.5 μM, (B) 1 μM, and (C) 2 μM; incubation with OnIr3 and OnIr4 was performed at a concentration of (A) 1 μM, (B) 2 μM, and (C) 3 μM. (c) Cellular content of bcl-2, bax and ChChd3 in A549R cells.