Figure 3.

Whole-cell clamp time constant limits eM frequency response. A, Left panel shows NLC in an OHC, whose eM was measured at three different values of R_s (achieved through amplifier R_s compensation circuitry). As clamp time constant is decrementally reduced (clamp τ ≈ R_s * C_m), eM frequency response approaches that of NLC. Symbols correspond for all plots. B, Magnitude–frequency plot illustrating enhanced frequency response of eM at V_h. C, Linear relationship between eM and clamp time constants. eM τ_Vh approaches this cell's NLC τ_Vh, determined from a single exponential fit (blue asterisk). Stimulus was 15 mV peak at each frequency.