Figure 4.
Models show that kinetics underlying NLC frequency response restrain frequency response of eM (Qp). A, NLC of a two-state Boltzmann model is frequency independent. However, eM (Qp; right) faithfully follows clamp time constant. B, NLC of meno presto model incorporating slow multiexponential kinetics is low-pass. Note that eM (Qp) frequency response is also increased by reducing clamp time constant, but is limited by kinetics that define NLC response. AC stimulus was 15 mV peak at each frequency.