Chart 1.

Clinical criteria for the diagnosis of tuberous sclerosis complex

Major criteria	Minor criteria
1. Hypomelanotic macules (≥ 3,≥ 5mm in diameter)	1. "Confetti" skin lesions
2. Angiofibromas (≥ 3) or fibrous cephalic plaque	2. Dental enamel pits (> 3)
3. Ungual fibromas (≥ 2)	3. Intraoral fibroma (≥ 2)
4. Shagreen patch	4. Retinal achromic patch
5. Multiple retinal hamartomas	5. Multiple renal cysts
6. Cortical dysplasia	6. Nonrenal hamartomas
7. Subependymal nodules
8. Subependymal giant cell astrocytoma
9. Cardiac rhabdomyoma
10. Lymphangioleiomyomatosis
11. Angiomyolipomas (≥ 2)