Table 1.
S. mitis type strain and SK321 upregulated orthologues of S. pneumoniae early genes in response to CSP in C + YYB
| Gene ID | Mean fold-changec | |||||
|---|---|---|---|---|---|---|
| TIGR4b | NCTC12261a | SK321a | NCTC12261 | SK321 | R6d | Description |
| Orthologues of early genes | ||||||
| 0014 | 0014 | 1251 | 3.4 | 71.2 | ↑ | Competence-specific global transcription modulator; sigX1 |
| 0018 | 0016 | 0337 | 1.8 | 10.8 | ↑ | Conserved hypothetical protein; comW |
| 0019 | 0017 | 0338 | 1.8 | 6.5 | ↑ | Adenylosuccinate synthetase; purA |
| 0042 | 0048 | 1310 | 8.3 | 41.6 | ↑ | ABC transporter CbaT; comA |
| 0043 | 0049 | 1311 | 6.9 | 48.3 | ↑ | Transport protein ComB; comB |
| 2006 | 0613 | 1651 | 3.1 | 36.3 | ↑ | Competence-specific global transcription modulator; sigX2 |
| 2237 | 0788 | 1635 | 1.7 | 3.58 | ↑ | Hypothetical protein; ComC |
| 2236 | 0787 | 1634 | 1.8 | 18.9 | ↑ | ComD |
| 2235 | 01116e | 00428e | 1.7 | 19.3 | ↑ | ComE |
| 1110 | 0833 | 0680 | 1.9 | 10.9 | ↑ | Riboflavin biosynthesis protein RibF; ribF |
| 1945 | 0911 | 1653 | 10.3 | 75.4 | ↑ | Lipoprotein. putative; comM |
| 1944 | 0912 | 1654 | 2.3 | 10.9 | ↑ | Conserved hypothetical protein |
| 1943 | 0913 | 1655 | 2.1 | 8.0 | ↑ | Acetyltransferase, GNAT family |
| 1942 | 0914 | 1656 | 1.9 | 6.9 | ↑ | Membrane-bound protein LytR |
| 1717 | 0940 | 1696 | 2.7 | 12.6 | ↑ | ABC transporter, ATP-binding protein |
| 1716 | 0941 | 1697 | 3.0 | 12.6 | ↑ | ABC transporter |
| 1549 | 1162 | 0137 | 2.7 | 17.1 | ↑ | Peptide deformylase |
| 1548 | 1163 | 0138 | 2.8 | 16.8 | ↑ | Conserved hypothetical protein |
| – | 1164 | 0139 | 1.5 | 22.0 | – | Conserved hypothetical protein |
| 1547 | 1165 | 0140 | 1.4 | 4.6 | – | Conserved hypothetical protein |
| 2156 | 0729 | 1581 | 1 | 2 | ↑ | SPFH domain-containing protein |
aGene number and product from HOMD
bGene number and product from [51]
cMean fold-change induction of CSP in S. mitis type strain and SK321 obtained by transcriptome analysis
dExpression pattern during response the of S. pneumoniae to CSP pheromone [9]
eGene number according to PROKKA annotation [52]