Table 1.
Variable | Patient 1 | Patient 2 | Patient 3 | Patient 4 |
---|---|---|---|---|
Age, years | 59 | 68 | 67 | 69 |
Number of days before LTx pirfenidone was stopped | 6 | 15 | 16 | 21 |
Pirfenidone dose at time of discontinuation | 801 mg PO TID | 801 mg PO TID | 801 mg PO TID | 801 mg PO TID |
Duration of pirfenidone treatment | 30-90 days | > 90 days | 30-90 days | < 30 days |
Reason for stopping pirfenidone | VV ECMO BTT with feeding tube | ECMO BTT with feeding tube | Cost | Adverse GI effects |
Prednisone dose at LTx | 10 mg PO daily | 10 mg PO daily | 20 mg PO daily | None |
Abbreviations: BTT bridge to transplantation, GI gastrointestinal, LTx lung transplantation, PO per oral, TID ter in die (3 times per day), VV ECMO venovenous extracorporeal membrane oxygenation