Table 2.
Bodyweight, blood glucose and echocardiographic assessment in non-diabetic (n = 10) and type 2 diabetic ZDF rats (n = 10)
| Parameter | 12 weeks | 20 weeks | Condition effect (p value) | ||
|---|---|---|---|---|---|
| nDM | DM | nDM | DM | ||
| ZDF rats | |||||
| Bodyweight (g) | 3.1 ± 0.1 | 375.3 ± 36.7 | 387.2 ± 7.9 | 442.9 ± 46.2 | 0.04* |
| Blood | 8.6 ± 1.9 | 16.8 ± 2.5 | 8.2 ± 0.6 | 25.0 ± 2.5 | 0.01* |
| Glucose (mmol/L) | |||||
| LVPWs (mm) | 3.1 ± 0.1 | 3.1 ± 0.1 | 2.9 ± 0.1 | 3.0 ± 0.1 | 0.60 |
| LVPWd (mm) | 2.5 ± 0.1 | 2.5 ± 0.2 | 2.3 ± 0.1 | 2.7 ± 0.1 | 0.18 |
| EF (%) | 77.2 ± 1.9 | 78.6 ± 1.2 | 72.2 ± 1.9 | 69.9 ± 3.9 | 0.84 |
| LVESV (mL) | 0.2 ± 0.0 | 0.2 ± 0.0 | 0.3 ± 0.0 | 0.5 ± 0.1 | 0.21 |
| LVEDV (mL) | 0.8 ± 0.1 | 1.0 ± 0.0 | 1.1 ± 0.1 | 1.4 ± 0.2 | 0.04* |
| E:A | 1.9 ± 0.1 | 2.0 ± 0.1 | 1.8 ± 0.1 | 2.0 ± 0.1 | 0.08 |
| E vel (cm/s) | 1.9 ± 0.1 | 54.3 ± 2.2 | 55.1 ± 2.3 | 57.1 ± 3.0 | 0.52 |
| A vel (cm/s) | 1.9 ± 0.1 | 27.4 ± 1.5 | 31.7 ± 2.1 | 29.2 ± 2.3 | 0.11 |
Data are expressed ± SEM
nDM nondiabetic, DM type 2 diabetic ZDF rats, LVPWs left ventricle posterior wall thickness systole, LVPWd left ventricle posterior wall thickness diastole, EF ejection fraction, LVESV end systolic volume, LVEDV end diastolic volume
For comparison of condition effect between nDM and DM at 12 and 20 weeks of age in all parameters two between groups ANOVA, * p < 0.05