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. 2018 Jun 14;20:56. doi: 10.1186/s13058-018-0975-1

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — pCR in an HER2-positive tumor in a 51-year-old woman with a high-grade invasive ductal carcinoma treated with TPT every 3 weeks for six cycles. Left panel: US images obtained at pretreatment, at day 7, at the completion of cycle 1, and before surgery. Right panel: tHb concentration maps obtained at the corresponding time points. Each map shows seven subimages marked as slice 1 to 7, and each subimage shows spatial x and y distribution of tHb concentration reconstructed from 0.5 cm to 3.5 cm below the skin surface. The depth spacing between the subimages in depth is 0.5 cm. The color bar is tHb in micromoles per liter. This patient had a complete pathologic response with no residual tumor, Miller-Payne grade 5