Fig. 7. Structural mapping of oncogenic mutations in the short α-helix across the human kinome: the spatial distribution of highly oncogenic mutations in the catalytic core of kinases (ABL1, BRAF, KIT, FLT3, PDGFRα, ALK, ErbB2, BTK, MET, KDR, and EGFR). The kinase mutations with known high oncogenic potential were mapped onto the kinase catalytic domain of EGFR^WT in its inactive form. Structurally conserved hotspots of kinase cancer mutations are annotated (number corresponds to the EGFR^WT kinase) with spheres and their locations is indicated by arrows.