Figure 3.

Systemic interactions between immunological biomarkers is abnormal in patients with myeloproliferative neoplasms. The network analysis shows significant correlations (p < 0.05) between cytokines and chemokines in healthy subjects (CTRL, Panel A) and in patients with primary myelofibrosis (PMF; Panel B), polycythemia vera (PV; Panel C), and essential thrombocythemia (ET; Panel D). The ‘r’ values obtained after the Spearman's correlation analysis were used to determine the correlation strength: negative (r < 0), weak (r ≤ 0.35), moderate (0.36 ≤ r ≤ 0.67), or strong (r ≥ 0.68).