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. 2018 Feb 24;11:160–177. doi: 10.1016/j.molmet.2018.02.010

Figure 6.

Figure 6

A high-fat diet fail to induce glucose and insulin intolerance in mice lacking muscle OGT. (A) Weekly (Wk) body weights of WT and mKO mice during 24 wks of HFD. HFD feeding started at 4 weeks of age. (B) Cross-sections of the tibialis anterior (TA, top row) muscle and inguinal WAT (IngW, bottom row) of WT (left column) and mKO (right column) mice fed HFD for 24 wks. (C) Photo micrographs of H&E stained liver (top row) and pancreas (bottom row) sections of WT (left column) and mKO (right column) mice fed HFD for 24 wks. (D) Blood glucose levels of WT and mKO mice fed a HFD for 12 wks and fasted for 4 and 16 h, respectively. (E) Blood glucose levels in WT and mKO mice fed a HFD for 22 wks and fasted for 4 and 16 h, respectively. (F–G) Glucose (F) and insulin (G) tolerance tests of WT and mKO male mice fed a HFD for 12 wks (H–I) Glucose (H) and insulin (I) tolerance tests of WT and mKO male mice fed a HFD for 22 wks. Data represent means ± SEM from n = 12 male mice in each genotype. *p < 0.05; **p < 0.01; ***p < 0.001 compared with WT control mice.