Table 3.
Resistance folds for a panel of mutant HIV-1 stains of selected compounds in MT-4 cells.
| No. | Resistance Foldsa
|
|||||
|---|---|---|---|---|---|---|
| L100I | K103 | N E138K | Y181C | Y188L | F227L + V106A | |
| 3b1 | 52.7 | 11.1 | 1.1 | 6.2 | 85.7 | 21.1 |
| 3b2 | 53.0 | 12.5 | 0.8 | 4.5 | 112.0 | 16.5 |
| 3b3 | 34.5 | 9.0 | 0.9 | 5.5 | 110.3 | 20.3 |
| 3b7 | 20.5 | 6.0 | 0.9 | 4.8 | 25.9 | 10.5 |
| 3b8 | 48.0 | 13.5 | 0.7 | 4.3 | 74.0 | 12.0 |
| 3b9 | 306.5 | 19.0 | 1.4 | 12.0 | 358.0 | 30.5 |
| NVP | 3.2 | 26.1 | 0.9 | 23.9 | 37.0 | 27.6 |
| DLV | 66.8 | 78.9 | 1.3 | 64.7 | 22.1 | 59.7 |
| EFV | 20.0 | 24.0 | 1.0 | 1.4 | 68.0 | 42.0 |
| ETR | 1.7 | 0.8 | 3.5 | 4.0 | 2.8 | 1.2 |
| AZT | 0.7 | 1.2 | 1.9 | 1.0 | 1.6 | 0.7 |
a
Resistance Fold: RF, ratio of EC50 against mutant strain/EC50 against WT strain.