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. Author manuscript; available in PMC: 2019 May 10.
Published in final edited form as: Eur J Med Chem. 2018 Mar 23;151:339–350. doi: 10.1016/j.ejmech.2018.03.059

Table 4.

Selectivity against a panel of mutant HIV-1 stains of selected compounds in MT-4 cells.

No. SIa
L100I K103 N E138K Y181C Y188L F227L + V106A
3b1 13 62 651 109 8 32
3b2 38 158 2631 450 18 121
3b3 19 73 756 123 6 33
3b7 7 23 159 29 5 13
3b8 60 214 4189 686 39 245
3b9 30 473 6800 761 25 297
NVP >18 >2 >64 >2 >2 >2
DLV 14 12 715 15 44 16
EFV >62 >52 >1235 >928 >19 >30
ETR 370 773 179 159 111 143
AZT >1444 >901 >581 >1058 >704 >1544
a

SI: selectivity index, the ratio of CC50/EC50.