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. Author manuscript; available in PMC: 2019 May 10.
Published in final edited form as: Eur J Med Chem. 2018 Mar 23;151:339–350. doi: 10.1016/j.ejmech.2018.03.059

Table 5.

Activity against NL4-3 HIV-1 strain, cytotoxicity and SI of compounds 3b8, 3b9 and RPV in TZM-bl cells.

No. EC50 (nM)a CC50 (nM)b SIc
3b8 24 ± 5 >221 >9.2
3b9 20 ± 5 >215 >10.8
RPV 0.9 ± 0.3 >341 >378.9
a

EC50: Concentration of compound that causes 50% inhibition of viral infection, presented as the mean ± standard deviation (SD) and determined in at least triplicate against HIV-1 in TZM-bl cells.

b

CC50: Concentrations that cause cytotoxicity to 50% of cells; CytoTox-Glo cytotoxicity assays (Promega) were used, and values were averaged from two independent tests.

c

SI: selectivity index, the ratio of CC50/EC50.