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. 2018 May 18;145(10):dev153619. doi: 10.1242/dev.153619

Fig. 11.

Fig. 11.

Downregulation of the Notch/HNF network in Six2GC;Hdacflox/flox,Hdac2flox/flox kidneys. (A,B) Network analysis of differentially expressed genes shows altered (mostly decreased) genes that are downstream of Lhx1 and Hnf1a/4a. Green, downregulated; red, upregulated. Numbers indicate fold change versus WT. (C,D) Section ISH showing downregulation of Hhf1a/4a (but not Hnf1b) and Notch genes in HDAC1/2 mutant kidneys. HNF1A/HNF4A control expression of a network of genes involved in metabolic and transport functions in the proximal tubules. Decreased HNF1A-mediated gene expression is likely secondary to downregulation of Notch signaling, which controls segmental tubular differentiation.