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NPC-specific deletion of Hdac1 and Hdac2 causes severe renal hypodysplasia. (A-I) Gross and histological morphology in wild-type (WT) (A,D,G), and conditional compound heterozygous (B,E,H) and homozygous null (C,F,I) HDAC1/2 mutant mice. Six2-Cre-mediated deletion of HDAC1/2 impairs renal growth and patterning owing to loss of the nephrogenic zone (NZ) and cystic tubular degeneration.
