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. 2018 May 18;145(10):dev153619. doi: 10.1242/dev.153619

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© 2018. Published by The Company of Biologists Ltd

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Fig. 8. — RVs lacking HDAC1/2 fail to express the transcription factor Lhx1. (A-F) Section IF for Six2/Lhx1 (A,B), HDAC2/Lhx1 (C,D), and laminin/HDAC2 (E,F) showing abrogated Lhx1 protein expression in nascent nephrons of HDAC1/2-mutant kidneys, which correlates spatially with loss of HDAC1/2. (G,H) The few instances in which Lhx1 expression was preserved correlate with nascent nephrons that escaped Cre-mediated excision of HDAC1/2. Arrows indicate the different stages of nascent nephrons: renal vesicle (RV), comma-shaped body (CB) and S-shaped body (SB).