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. 2018 Mar 15;11:113–128. doi: 10.1016/j.molmet.2018.03.006

Figure 2.

Figure 2

Serum IGF1, IGFBP and GH concentrations of GHR-KO compared with control pigs. (A) Scatter plot of serum IGF1 levels of GHR-KO and control pigs over time. (B) Means and standard deviations of all serum IGF1 values displayed in panel A (GHR-KO: n = 42; control: n = 69). (C) Representative IGFBP ligand blot. Right lane displays recombinant human IGFBP3 (41/38 kDa), IGFBP2 (32 kDa), IGFBP5 (29 kDa) and IGFBP4 (24 kDa). (D) Quantification of IGFBP3 and IGFBP2 in serum from GHR-KO (n = 10) and control pigs (n = 12). The figure shows medians, 25th and 75th percentiles (box), and extremes (whiskers). (E) Representative GH secretion profiles of two female GHR-KO and two female control pigs. (F) Area under the GH curve (AUC; means and standard deviations for 6 female GHR-KO and 5 female/1 male control pigs). AU = arbitrary units. *p < 0.05; ***p < 0.001.