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. 2018 Mar 15;11:113–128. doi: 10.1016/j.molmet.2018.03.006

Figure 4.

Figure 4

Body composition of 6-month-old GHR-KO compared with control pigs. (A) DXA analysis revealed a significantly higher amount of total body fat in GHR-KO pigs. (B) The calculated ratio of muscle to fat tissue from MRI images at the last rib revealed a significant shift towards fat tissue in GHR-KO pigs (GHR-KO: n = 12; control: n = 25; ***p < 0.001). Panels A and B show least squares means (LSMs) and standard errors of LSMs estimated for the 2 groups (see 2.8 for the statistical model). (C) Representative magnetic resonance images used to evaluate the volume of the longissimus dorsi muscle (mu) and its overlying back fat (ft) at the last rib in GHR-KO and control pigs. Note the larger subcutaneous and visceral fat depots in GHR-KO pigs. (D) Representative macroscopic cross-sections of the first lumbar vertebra, the two longissimus dorsi muscles and the overlying back fat and skin. (E) Higher magnification of D showing an increased ratio of subcutaneous fat (ft) to skin (sk) thickness in a GHR-KO compared with a control pig. Histological section (H&E stain) showing an increased amount of intramuscular fat in GHR-KO pigs (bar = 100 μm).