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. 2018 Mar 15;11:113–128. doi: 10.1016/j.molmet.2018.03.006

Figure 6.

Figure 6

Age-dependent changes in glucose and lipid homeostasis parameters in GHR-KO and control pigs. (A) Transient juvenile hypoglycemia in GHR-KO pigs. (B) Unchanged serum insulin concentrations. (C) Initially lower, then higher HOMA-IR score (interaction group*age: p < 0.05). Serum concentrations of (D) triglycerides, (E) cholesterol, (F) low-density lipoprotein (LDL)-cholesterol, and (G) high-density lipoprotein (HDL)-cholesterol levels were significantly lower in young GHR-KO pigs than in age-matched controls, but normalized with age. HDL-cholesterol levels of 23- to 27-week-old GHR-KO pigs were even higher than in their control littermates. At least 6 animals per group and age-class were investigated. Panels A–G show least squares means (LSMs) and standard errors of LSMs estimated for group*age (see 2.8 for the statistical model). *p < 0.05; **p < 0.01.