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. 2018 Mar 15;11:113–128. doi: 10.1016/j.molmet.2018.03.006

Figure 8.

Figure 8

(A) Schematic summary of the changes in phosphorylation in INSR- and GHR-related signaling molecules in liver samples of GHR-KO compared with control pigs. *p < 0.05; °p = 0.0635; evaluated using the Mann–Whitney U test. (B) Significantly increased fasting serum leptin concentrations in 6-month-old GHR-KO vs. control pigs. The figure shows the estimated least squares means (LSMs) and standard errors of the LSMs for the two groups, taking into account the effect of sex (9 male/13 female control pigs; 6 male/6 female GHR-KO pigs). **p < 0.01 for the effect of group (PROC GLM). (C) Significantly increased expression and phosphorylation of LEPR in liver samples from GHR-KO compared with control pigs. PC = protein lysate from choroid plexus of a wild-type pig used as positive control. *p < 0.05; evaluated using the Mann–Whitney U test.