Fig. 2. Sequential borylation/oxidation of 2-(hetero)aryl substituted 1,3-dienes. Reaction conditions: 1a (0.36 mmol), B2(pin)2 (0.30 mmol). Chemoselectivity assessed by 1H NMR after borylation. Yields of isolated alcohols 2′. Enantioselectivity determined after oxidation by HPLC, GC or SFC using a chiral stationary phase. aThe minor isomer is 4′n. bIsolated as a 5 : 1 mixture.
