Fig. 3. Sequential borylation/oxidation of 2-alkyl substituted 1,3-dienes. Reaction conditions: 1u-x (0.18–0.36 mmol), B2(pin)2 (0.15–0.30 mmol). Chemoselectivity assessed by 1H NMR after borylation. Isolated yields for alcohols 2′v-x. Enantioselectivity determined after oxidation by HPLC, GC, SFC using a chiral stationary phase. aConversion of non-separable isomers determined by 1H NMR (2′u + 3′u). bAt 0 °C for 24 h.
