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. 2018 Mar 15;11:145–159. doi: 10.1016/j.molmet.2018.03.005

Figure 3.

Figure 3

Position of miR-31 in the obesity QTL Nob6 on chromosome 4, the predicted and validated targets and differentially expressed genes in gWAT of B6 and NZO mice. (A) Peak regions of the QTL for body weight (BW) in week 6/14 and weight of gWAT. Peak of LOD-score is added to the bottom axis. (B) Comparison of differently expressed genes in gWAT with predicted targets and experimentally validated targets of miR-31. (C) Pathway enrichment analysis for the 416 target genes of miR-31 in gWAT, filtered for a fold enrichment >3 and p < 0.1. (D) Heat map for a two-dimensional genome scan with a two-QTL model for the NZOxB6 cross. The maximum LOD score for the interaction model (locus to locus interaction) in the upper left triangle. The maximum LOD score for the full model (two QTLs plus additive effect) is indicated in the lower right triangle. Black squares show an interaction between miR-31 and predicted genes (Foxo1, Hk2, Irs1, Glut4, Acaca), LOD-score >6 (dark red). gWAT: gonadal white adipose tissue.