Figure 4.

Effect of saroglitazar, fenofibrate and pioglitazone on hepatic mRNA levels in CDAHFD‐induced NASH model. Hepatic mRNA levels were determined using SYBR Green quantitative real‐time polymerase chain reaction and normalized to β‐actin mRNA expression. The data are expressed as the fold change vs the Control diet for CDAHFD‐Vehicle. Values are expressed as the means ± SEM (n = 6). ^# P < .05 vs control diet‐vehicle‐treated group, *P < .05 and **P < .01 vs CDAHFD vehicle‐treated group. Col1α1, collagen type I, alpha 1; CTGF, connective tissue growth factor; MCP‐1, monocyte chemotactic protein‐1; MMP9, matrix metallopeptidase 9; TIMP, tissue inhibitor of metalloproteinase; TNFα, tumour necrosis factor α; αSMA, alpha smooth muscle actin