Table 1.
Symptoms of early OHSS using different triggers
| Univariate analyses | Multivariate analyses | |||
|---|---|---|---|---|
| Odds ratio (CI) | P value | Adj odds ratio (CI) | P value | |
| Abdominal paina | ||||
| hCG | 16.1 (6.7‐38.3) | <.001 | 13.1 (4.2‐40.6) | <.001 |
| GnRHa | 2.1 (1.01‐4.2) | .048 | 2.1 (1.01‐4.2) | .048 |
| Abdominal bloatingb | ||||
| hCG | 35.3 (13.1‐94.8) | <.001 | 30.7 (7.0‐134.3) | <.001 |
| GnRHa | 3.4 (1.7‐6.9) | .001 | 3.7 (1.5‐9.4) | .005 |
| Diarrhoeac | ||||
| hCG | 8.8 (1.6‐47.5) | .011 | 2.9 (0.2‐35.8) | .41 |
| GnRHa | 1.9 (0.3‐11.6) | .489 | 2.4 (0.4‐14.9) | .35 |
| Nausead | ||||
| hCG | 24.8 (6.7‐92.3) | <.001 | 19.4 (3.3‐115.4) | .001 |
| GnRHa | 6.6 (1.8‐23.7) | .004 | 8.2 (1.8‐37.6) | .007 |
| Vomitinge | ||||
| hCG | 10.1 (1.02‐99.9) | .048 | 10.1 (1.02‐99.9) | .048 |
| GnRHa | 5.1 (0.6‐46.8) | .15 | 5.1 (0.6‐46.8) | .15 |
| Self‐reported reduction in urine outputa | ||||
| hCG | 13.8 (1.5‐127.8)f | .021 | 16.1 (1.4‐188.8)f | .027 |
| GnRHa | 2.5 (0.2‐28.2)f | .45 | 2.5 (0.2‐28.2)f | .45 |
Univariate and multivariate logistic regression analysis of associations between symptom of early OHSS following different triggers. The odds ratio of experiencing symptoms of OHSS following hCG or GnRH trigger when compared with kisspeptin trigger is presented as follows: aadjusted for use of long IVF protocol, badjusted for use of long IVF protocol and number of oocytes retrieved, cadjusted for antral follicle count and use of long IVF protocol, dadjusted for antral follicle count, total dose of recombinant FSH during stimulation and use of long IVF protocol, eno confounders identified during univariate analysis. fAs no patient with kisspeptin triggering had self‐reported reduction in urine output, Laplace smoothing was applied.