Table 2.
Rates of early OHSS using different triggers
| N | Normal | Mild OHSS | Moderate OHSS | Severe OHSS | Odds ratio of mild‐severe OHSS (95% CI) | Odds ratio of moderate‐severe OHSS (95% CI) |
|---|---|---|---|---|---|---|
| hCG (n = 40) | 7 (18%) | 18 (45%) | 9 (23%) | 6 (15.0%) | 33.6 (12.6‐89.5) P < .0001 | 80.7a (10.2‐637.5) P < .0001 |
| GnRHa (n = 99) | 66 (67%) | 30 (30%) | 3 (3%) | 0 (0%) | 3.6 (1.8‐7.1) P < .0001 | 5.1a (0.6‐46.3) P = .15 |
| Kisspeptin (n = 122) | 107 (88%) | 15 (12%) | 0 (0%) | 0 (0%) | ‐ | ‐ |
The frequency (%) of the number of patients diagnosed with mild, moderate and severe OHSS is presented.
Patients were objectively graded based on modified criteria of Golan et al 19891 as below:
Normal—Patients without any symptoms consistent with OHSS were graded as normal.
Mild OHSS—Patients with at least one symptom consistent with OHSS and maximal ovarian volume (either left or right ovary) of 65‐903 ml (approximated to 5‐12 cm diameter) were graded as mild OHSS.
Moderate OHSS—If patients met the above criteria for mild OHSS and additionally had at least 50 ml of total ascitic fluid in the pouch of Douglas, adnexae and abdomen, they were graded as moderate OHSS.
Severe OHSS—If patients met the above criteria for moderate OHSS, but additionally had at least 50 ml of fluid in the pleural space, they were graded as severe OHSS.
Rates of OHSS were compared by logistic regression: as no baseline variables were significant during univariate analyses, unadjusted odds ratios (95% confidence interval) are presented for hCG and GnRH agonist trigger as compared to kisspeptin trigger. Mild to severe OHSS was compared to “no OHSS,” whilst moderate‐severe OHSS was compared to “normal to mild OHSS.”
aAs no patient with kisspeptin was diagnosed with moderate OHSS, Laplace smoothing was applied.