Figure 8.

The protective effects of miR‐34b‐5p are dependent on PGRN. Mice were subjected to the miR‐34b‐5p antagomir after administration of Ad‐PGRN‐shRNA or the NC (Ad‐GFP) for 7 days. After 48 hr, the mice were administered with LPS by intratracheal injection for 24 hr. (a) Representative images of the lung lesions in the lung sections by HE staining. Scale bar = 50 µm, n = 4. (b) Quantitation of the lung injury scores in the different treatment groups. (c) The caspase‐3 activity of the lungs in the different treatment groups, n = 4. The levels of (d)IL‐1β, (e)TNF‐α, and (f) IL‐6 in the BALF were assessed by ELISA. *p < 0.05. Data are presented as the mean ± SD