Fig. 6. Allergic inflammation in response to HDM.

Mice were challenged with HDM as described in the Materials and Methods. a Ear thickness and (b-d) serum IgE, histamine, and HMGB1were analyzed (n = 6). e Paraffin-embedded skin sections were prepared and stained with H&E and toluidine blue. Bars = 100 μm. Epidermal and dermal thicknesses were measured in H&E-stained microphotographs (n = 6). Values are means ± SEMs. ^**p < 0.01 vs. WT; ^##p < 0.01 vs. WT+HDM