Table 3.
Cross‐twin familial co‐aggregation analysis. Initial analyses and MZ and DZ same‐sex analyses
| Depression or anxiety in Twin 2 | Odds Ratios (95% Confidence Intervals) for the association of atopic disease in twin 1 and depression or anxiety in twin 2 | |||||
|---|---|---|---|---|---|---|
| Atopic Diseases in Twin 1 | n (% of twin 1 with atopic disease) | n (% of twin 1 without atopic disease) | All twin pairsa | All twin pairsaadjusted for twin 2 atopic status | MZ twinsa | DZ same‐sex twinsa |
| Ever | ||||||
| ≥1 atopic disease | 780 (15.2) | 918 (11.7) | 1.25 (1.12, 1.40)*** | 1.24 (1.12, 1.39)*** | 1.17 (0.94, 1.46) | 1.25 (1.05, 1.50)* |
| Asthma | 314 (17.2) | 1384 (12.4) | 1.33 (1.14, 1.54)** | 1.29 (1.12, 1.49)** | 1.18 (0.88, 1.59) | 1.35 (1.06, 1.72)* |
| Eczema | 455 (16.2) | 1243 (12.2) | 1.30 (1.14, 1.48)*** | 1.32 (1.16, 1.50)*** | 1.36 (1.05, 1.78)* | 1.28 (1.04, 1.58)* |
| Hay fever | 166 (17.8) | 1532 (12.7) | 1.39 (1.14, 1.68)** | 1.40 (1.16, 1.68)** | 1.20 (0.81, 1.77) | 1.25 (0.91, 1.73) |
| Food allergy | 269 (16.0) | 1429 (12.6) | 1.24 (1.07, 1.45)** | 1.23 (1.05, 1.42)** | 1.34 (1.01, 1.79)* | 1.05 (0.80, 1.37) |
| Current | ||||||
| ≥1 atopic disease | 474 (15.5) | 1224 (9.4) | 1.23 (1.08, 1.39)** | 1.22 (1.08, 1.37)** | 1.36 (1.06, 1.75)* | 1.08 (0.88, 1.33) |
| Asthma | 187 (17.1) | 1511 (12.7) | 1.22 (1.02, 1.46)* | 1.23 (1.03, 1.46)* | 1.14 (0.78, 1.66) | 1.40 (1.05, 1.87)* |
| Eczema | 172 (17.7) | 1524 (12.7) | 1.45 (1.20, 1.76)*** | 1.45 (1.20, 1.76)*** | 2.07 (1.46, 2.94)*** | 1.08 (0.76, 1.55) |
| Hay fever | 146 (17.5) | 1548 (12.8) | 1.38 (1.12, 1.69)** | 1.39 (1.14, 1.70)** | 1.12 (0.73, 1.71) | 1.27 (0.91, 1.78) |
| Food allergy | 182 (15.3) | 1516 (12.9) | 1.15 (0.96, 1.37) | 1.15 (0.96, 1.36) | 1.33 (0.96, 1.82) | 0.94 (0.68, 1.29) |
N = 12 474 (those with all information who have a twin with all information).
Adjusted for gestational age and maternal age at delivery.
* P ≤ .05, **P < .01, ***P < .001.