. 2018 Apr 1;48(6):703–711. doi: 10.1111/cea.13127

Table 4.

Cross‐twin familial co‐aggregation analysis. Testing potential familial candidates

	Odds ratios (95% Confidence intervals) for the association of atopic disease in Twin 1 and depression or anxiety in Twin 2
Atopic diseases in Twin 1	All twin pairs^aadjusted for parental education	All twin pairs^aadjusted for recent maternal psychological stress	All twin pairs^aadjusted for family trauma	All twin pairs^aadjusted for parental birth place
Ever
≥1 atopic disease	1.26 (1.12, 1.40)***	1.23 (1.10, 1.37)^**	1.25 (1.12, 1.39)***	1.27 (1.14, 1.42)***
Asthma	1.31 (1.13, 1.53)^**	1.30 (1.12, 1.50)^**	1.32 (1.14, 1.53)^**	1.36 (1.17, 1.58)^**
Eczema	1.30 (1.14, 1.48)***	1.29 (1.13, 1.47)^**	1.30 (1.14, 1.47)***	1.31 (1.15, 1.49)***
Hayfever	1.42 (1.17, 1.72)^**	1.37 (1.12, 1.66)^**	1.37 (1.13, 1.67)^**	1.41 (1.16, 1.71)^**
Food allergy	1.22 (1.04, 1.42)^*	1.22 (1.05, 1.43)^**	1.23 (1.05, 1.43)^**	1.26 (1.08, 1.46)^**
Current
≥1 atopic disease	1.22 (1.08, 1.39)^**	1.20 (1.06, 1.36)^**	1.22 (1.08, 1.38)^**	1.25 (1.10, 1.442)^**
Asthma	1.21 (1.02, 1.44)^*	1.18 (0.98, 1.42)	1.22 (1.03, 1.45)^*	1.25 (1.04, 1.50)^*
Eczema	1.45 (1.19, 1.76)^**	1.44 (1.18, 1.75)^**	1.46 (1.20, 1.77)^**	1.48 (1.22, 1.80)***
Hayfever	1.41 (1.15, 1.73)^**	1.35 (1.10, 1.66)^**	1.36 (1.11, 1.67)^**	1.41 (1.15, 1.73)^**
Food allergy	1.15 (0.96, 1.38)	1.12 (0.94, 1.35)	1.14 (0.95, 1.36)	1.16 (0.97, 1.39)

N = 12 474 (those with all information who have a twin with all information).

^aAdjusted for gestational age and maternal age at delivery.

* P ≤ .05, **P < .01, ***P < .001.