Table 1.

Indicative renal transplant demographics from WTCCC3 and the validation cohort. For consistency, numbers refer to transplants where both donors and recipients passed QC (“complete” donor‐recipient pairs)

	WTCCC3 (post QC)	%	Replication cohort	%
Total transplants where both donors and recipients passed QC	2094	100	5866	100
Total unique donors with a paired recipient	1850	100	5027	100
Total unique recipients with a paired donor	2086	100	5866	100
Mean donor age ± SD	43 ± 15.4		43 ± 16.7
Mean recipient age ± SD	45 ± 13.3		48 ± 13.6
0 previous grafts	1864	89	N/A
1 previous graft	204	9.7	N/A
2 or more previous grafts	26	1.2	N/A
Graft survival time (days‐to‐uncensored‐event, 25% quartile)	902		442
Graft survival time (days‐to‐uncensored‐event, median)	1866		1769
Graft survival time (days‐to‐uncensored‐event, 75% quartile)	3165		3162
0 HLA mismatches	223	10.7	N/A
1 or 2 Class I HLA mismatches	839	40.1	N/A
1 or 2 Class II HLA mismatches	20	0.96	N/A
1 or 2 mixed Class I/II HLA mismatches	124	5.9	N/A
3 to 5 HLA mismatches	612	29.2	N/A
6 HLA mismatches	8	0.4	N/A
N/A HLA mismatches	268	12.8	N/A
Graft survival: total uncensored	495	23.6	2951	50.3
Graft survival: total censored	1599	76.4	2915	49.7
Total double‐kidney transplants	3	0.14	N/A
Total en bloc kidney transplants	1	0.05	N/A
Total kidney+pancreas transplants	16	0.76	N/A
Total kidney‐only transplants	2074	99.0	N/A
Total rejections (first 3 mo)	259	12.4	N/A
Total no rejections (first 3 mo)	915	43.7	N/A
N/A rejections (first 3 mo)	920	43.9	N/A
Total rejections (3‐12 mo)	221	10.6	575	9.8
Total no rejections (3‐12 mo)	946	45.2	2573	43.9
N/A rejections (3‐12 mo)	927	44.3	2718	46.3

N/A, data not available; QC, quality control; WTCCC3, Wellcome Trust Case Control Consortium‐3.