Figure 4.

The mineralization rate in the Dmp1 null (KO) dentin is sharply reduced in both the mineralization front and inside dentin matrices surrounding dentin tubules. a. P13 pulps (WT and Dmp1 KO) were labelled with calcein and alizarin red 5 days apart and harvested for confocal imaging mineralization status; and b. The cross (upper panels) and sagittal (lower panels) views in the Dmp1 KO dentin (right panels) demonstrated 1) a great reduction in the mineralization rate; and 2) thin and sparse mineral labeling in both the mineralization front and inside dentin matrices.